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He ought to be able to do so without constantly taking shots at anyone.

He's not so much taking shots as being a bit of a sea-lion. I can understand how it's annoying, but aspies gonna aspie.

Why?

It's not just Scott, the sum total of hostility towards ivermectin, combined with the absolute refusal to debate Alexandros on the merits of the arguments comes off as "oh shit, he makes good points, that I don't know how to argue against". I'm not saying Scott has to talk to him, but it if he's so obviously wrong, shouldn't there be someone among the science trusting cloutsharks that would be happy to take him on?

That's the thing about sealioning, though.

It's an asymmetric strategy. Marinos will expend more time and effort constructing his castle than 99% of readers can spend attacking it. He's made that his brand--he makes money off of angry skeptics who want to signal they "do your own research."

But what about the other 1%? You make a good point about the absence of Trust Science clout-chasers. They don't seem too eager to take on his fortified position. If I had to guess, I'd say they're off on a different part of Twitter, building up their own forts, because that's their brand.

I'm honestly not sure I want to see those deboonkers come out and get into a slapfight with Marinos. I don't really trust them for the same reasons. They're showing up to make money and promote the brand. A showdown between two open partisans (pretending to be neutral) is less appealing than a polite conversation between two reasonable authors.

Truth-seeking is supposed to be a two-way street, and all I see from Marinos is one-way. Should some commenter point out "hey, strongyloides was theorized to stress the immune system, not kill through hyperinfection!" or "I reran the meta-analysis and got blah blah blah," does Marinos pick that up and signal-boost it? Does he have any reason to do so? His fame is based on giving reasonable arguments for ivermectin. He doesn't have to answer to random commenters unless he thinks he can score points off them. I've seen that happen on reddit, most clearly here and here. Note the lack of any concessions, just claims that he welcomes criticism, followed by grilling anyone who remotely indicates skepticism.

Should some commenter point out "hey, strongyloides was theorized to stress the immune system, not kill through hyperinfection!" or "I reran the meta-analysis and got blah blah blah," does Marinos pick that up and signal-boost it?

Try it, and find out!