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PaperclipPerfector  25d ago (text post)   2848 thread views

Small-Scale Question Sunday for October 27, 2024

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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The specific example is interesting. I don't notice a damn thing from NSAIDs for pain that can reasonably be assumed to be inflammatory, and IIRC they're indistinguishable from placebo for osteoarthritis pain.

I found NSAIDs to do literally nothing for me for like 30 years across all sorts of injuries, then I encountered a very specific sort of neck-back ache resulting from poor form on power cleans that two ibuprofen instantly fixed. I could literally feel when the last dose would metabolize because the pain was so intense when present. I was basically chowing down on 8 pills a day for the week of that, otherwise I was unable to sleep or move my neck. Pain is weird.

Like I said pain is complicated, likewise pharm is complicated - some people are fast metabolizers of certain medication and get no effect at all.

Personally I find NSAIDs to be even better for low dose opiates for pain associated with significant inflammation (for me).

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