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PaperclipPerfector  11mo ago (text post)   4838 thread views

Small-Scale Question Sunday for December 10, 2023

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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[Omicron]

<1%? My vague memory is that there were a lot of variants, and that in general 'virus mutates to spread more and be less harmful' is fairly common, so imo there's not that much reason to believe this.

For a random variant I'd agree. But omicron was really weird in a lot of ways though, and I'd actually put this one at more like 30% (and 80% that something weird and mouse-shaped happened).

  1. Omicron was really really far (as measured by mutation distance) from any other sars-cov-2 variant. Like seriously look at this phylogenetic tree (figure 1 in this paper)
  2. The most recent common ancestor of B.1.1.529 (omicron) and B.1.617.2 (delta, the predominant variant at the time) dates back to approximately February 2020. It is not descended from any variant that was common at the time it started spreading.
  3. The omicron variant spike protein exhibited unusually high binding affinity for the mouse cell entry receptor (source)
  4. Demand for humanized mice was absurdly high during the pandemic - researchers were definitely attempting to study coronavirus disease and spread dynamics in mouse models.

The astute reader will object "hey that just sounds like a researcher who couldn't get enough humanized mice decided to induce sars-cov-2 to jump to normal mice, and then study it there. Why do you assume they intentionally induced a jump back to humans rather than accidentally getting sick from their research mice". To which I say "the timing was suspicious, the level of infectiousness was enormously higher in humans which I don’t think I'd expect in the absence of passaging back through humanized mice, and also hey look over there a distraction from my weak arguments".

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