SS: I think that cognitive genetic enhancement is important for ensuring we have a better and lasting future. Many people have an intuitive dislike for the idea of using genetic enhancement to make a baby smarter but have little issue with in vitro fertilization (IVF). I try to build from a foundation of the acceptable practice of IVF to PGT-P for IQ.
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This is an extension of the normal process of sexual selection that's been around with us as long as humans have been around. In practice, the society that does something like this will begin to resemble the many polygamous societies, which carries its own can of worms. (The padishah khan gets thousands of wives, his beys get dozens, his ghazi get two or three, and slave gets perhaps one if he's very lucky.) But I would not consider this transhumanism or autogenocide -- if perhaps unfair to the back half of the bell curve. Sexual selection is, on its own, a horror we have accustomed ourselves to to the point of not noticing -- but it is one that is intrinsic to our nature, much like eating brains is intrinsic to the botfly.
Gene editing for mental traits is an extremely obvious Schelling fence. It is hypothetically possible to do gene editing for certain mental traits that would not change the nature of humanity. However, I am confident if we take that step as a species, we will get Transhumanist-Gandhi, not 95%-Human-Gandhi.
What specific bad things will happen with 'transhumanism' that weren't already happening with natural gene editing, random mutation and combination of sequences? The genes that underlie biological functions were 'modified' - randomly mutating, duplicating, subsequences jumping from one place to another. And they are very useful!
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What could possibly go wrong?
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