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Notes -
I'd say I'm certainly open to hearing ideas and possibilities, but I'd like to hear something more specific than just we should go faster or we should skip trials. Which trials are we skipping, how are we dealing with the effects of skipping those trials? In my view, I've been trying this whole conversation to get out of you exactly what specifically you want to do, ideally something more generally applicable than, we did this specific bad thing during Covid, let's not do that. I mean, yeah, that's technically true, but how do you generalize that beyond, we should put better people in charge?
The mind boggles a bit trying to come up with general principles for addressing pandemics that would apply well to both of, let's say, Covid and Aids. If you can come up with some that don't just reduce down to putting better people in charge, by all means, let me know.
I am aware of what Human Challenge Trials are. Randomized Controlled trials are what we're already doing. I've got no problem with Human Challenge Trials, sounds like a good idea to me. It's at least a specific and actionable proposal. Liability might be a concern, but that ought to be solvable with waviers or some minor legislation. It's a relatively modest modification of current practice. It would likely result in full market availability somewhat sooner, though probably not dramatically so. The number of people accepted into such a trial would likely be modest. Though I gather you seemed interested in much more dramatic changes? Operation Warp Speed as it was actually executed produced far more dramatic timeline reductions just by bureaucratic optimization. Certainly nothing wrong with going even faster yet, but no need to forget what we actually did accomplish.
Another thing I'd note is that medical technology continues to advance incredibly fast. As far as I know, this was the first time in history we had a vaccine candidate ready for trials within weeks of the target viruses genome being isolated. That's freaking amazing! Can we come up with ways to get it verified and out to the public even faster than we actually did? Probably! But let's not beat ourselves up too bad, this stuff is all pretty new.
Great! That brings us back to about:
You now seem to have agreed with one of the specific proposals I mentioned (HCTs). How about the rest of the specific basics I mentioned, before we get into yet more specifics?
These should be pretty easy points of agreement, and it's always good to try to generate some nice easy agreement early on to show mutual positive sentiment and likely compatibility of underlying goals/schemas between interlocutors.
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