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I've thought about this a lot in trying to bootstrap something in the bio space. Even if I moved to Prospera tomorrow to escape the oppressive FDA, the CapEx required to get something off the ground is absurd. Simplest of animal studies is 10k a pop for really simple studies and more like 50-100k for the real disease relevant models, renting a single lab bench a month for myself is ~3.5-5k (maybe cheaper now that the biotech market has cratered), basic reagents run from a few thousand/month to 10s of thousands depending on what you're doing. Anything with human cells necessarily requires a bunch of infrastructure to do cell culture. There's also very few projects that lend themselves to producing an MVP and moving some units to fund more R&D; these are all decades-long slogs.
I joined a bunch of DIYbio mailing lists, discords and slack groups and the kinds of projects they do are just sad. More fit for high school ed than tackling any real problem.
The fact that you can buy a nice desktop for a few thousand and hack away in a fetid, windowless apartment for a few months or years to build a functional product seems to uniquely support innovation and, most importantly, give aggressive young founders a chance to lead a company. I'm interested to see whether the shift to training giant, prohibitively expensive AI models will lead to the same dynamics we see in biotech.
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