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There’s no psychopathology.

I’d like to start with a few disclaimers. This is not an anti-psychiatry post. This is also not the place to ask or receive advice about your mental health, or what nowadays is called “mental health”.

For some time now I’ve been feeling like I live in a different world than most people I know. It has come to a point where I have to face an awkward alternative: Either most people I know are wrong (including learned men and experts) or I am insane. As I don’t believe I have lost my sanity, and as I believe that I have very strong arguments to hold my ideas against all reasonable counterarguments; I think it’s about time I sit down and share my ideas more or less publicly. This is one of such ideas. What follows is the summary of my academic studies, my professional experience working in the field of mental health, my own personal thoughts, and the influence of several authors, chiefly Georges Canguilhem and Jacques Lacan.

The APA defines psychopathology as “the scientific study of mental disorders, including their theoretical underpinnings, etiology, progression, symptomatology, diagnosis, and treatment”. It is a jurisdiction of medicine, although that does not exclude other disciplines from delving into it as well. It is intrinsically linked to psychiatry, to the point where one cannot exist without the other. But psychiatry itself is a rather contradictory branch of medicine, because while every other specialization of medicine has built its own object of study by exploring a specific organ or function from the body, psychiatry exists only by virtue of that which it ignores. In its origins, psychiatry was born to deal with what has been classically classified as insanity, those people described by Descartes who believed they were made of glass or who fancied themselves to be pitches of water. These outlandish delusions have always caused turmoil in society because nobody really knows where they come from, what they mean and, most importantly, what to do with them. Insane people clearly need help but they do not want it, or what help they are willing to receive it’s impossible for other people to give. They break the law but they are not criminals, or at least they are bening. They behave like savages but are human beings and deserve to be treated as such.

Now enter the Enlightenment: Lady Reason triumphs all over the Western world, everything now has or will have a place and an explanation in the encyclopedia of universal knowledge. And what we understand we control. There are now a bunch of physicians who have little evidence but little doubt that these people are sick and that it is their task to heal them. And that they’ll try with all their available resources, but with little success. So while neurology developed from the study of the brain, cardiology from that of the heart and so on, psychiatry was born out of sheer embarrassment. It is the branch of medicine that studies mental disorders. However, being a part of modern scientific medicine, it cannot but assert that mental disorders can be explained by studying the body, the contradiction being that the day psychiatry discovers the bodily cause of mental disorders will be the day that it ceases to exist as a specialization of medicine, for said cause would fall under the jurisdiction of another specialization: If it’s in the brain then it would be neurology, if it’s in the genes it would be medical genetics, and if we were to discover a new organ in the body then a new specialization will be born to study it, leaving psychiatry in the past.

Therefore, psychiatry exists only because we do not know what mental disorders are. In fact, we don’t even know if the mind is real or not, much less whether it can get sick. What do we actually know then? We know that 1. there are people who need help, and 2. that there are means to help them. So it becomes a matter of administering a scarce resource. This is what psychopathology really is: It is not a science of mental pathology, it is the art of distributing psychiatric drugs and psychological treatments.

There used to be psychopathology. Classic psychiatrists wrote impressive treaties on the subject, with thousands of pages explaining in detail and classifying the behavior of their patients. The mountains really were in labour, alas, only a mouse was born: No progress was made regarding the causes, and most importantly the treatment of such behaviors. This last problem was drastically improved by the invention of psychopharmacology. Suddenly psychiatrists had a powerful tool to treat the symptoms of insanity, so even though they weren’t any close to understanding these symptoms, they changed their ideas on the subject to reflect the influence of psychiatric drugs. These influences can be accurately gauged by the changes on the DSM. The first DSMs included theories about the origin and nature of mental disorders, the last DSMs only mention the clinical symptoms necessary to prescribe a treatment. When a patient is diagnosed with depression the only relevant information that is learned is that said patient will start a treatment for depression.

So are mental disorders real? Of course they are. Whether they are mental or disorders, that’s another question. They are real because they are a set of behaviors that have been observed to occur together: Feelings of sadness, self-harming ideas or behaviors, inability to feel pleasure, these are all things that are real, observable, measurable, and treatable. But are these symptoms a mental problem? Are they a medical problem, or a problem at all? This is highly debatable, and in any case, not a solid foundation for a science.

If a person feels sad all the time, it is only natural for them to think that this life is not worth living. But the opposite is also true: If a person is convinced that there is nothing good in this world, then they will feel sad and hopeless all the time. So what comes first? Should we treat the sadness or the thoughts? And what if the person likes to feel sad, if they don’t want any help? Should we force them? And to make matters worse, it turns out that both psychiatric drugs and psychotherapy are effective*. And this is only to talk about those treatments that have empiric evidence to back them up and are approved by psychiatry, because, under the right circumstances, literally everything can be therapeutic: There’s horse therapy, art therapy, music therapy, dog therapy, video-game therapy, you name it.

There are some who believe in the demon deceptor, a person, or a group of people, who control our reality and make lies pass for truth, usually with malicious intent. These people believe that the pharmaceutical industry has created mental disorders only to sell drugs, and that psychologists and psychiatrists are their accomplices. For my part, I think it is overly optimistic to believe that someone has such a degree of control over the situation as to make it bend to their will. I believe that people are just confused, and with good reason, because being human is quite a bizarre experience. There are of course those who profit from the confusion of their fellow man, and prey on their ignorance. But even evil has its limits, and nobody can summon such perfect wickedness that no good may come of it. The truth is that for all the confusion that our idea of psychopathology entails, the treatment and the care for people with mental disorders has progressed a great deal in the last decades.

On the other hand there are the encyclopedists, who will argue that the fact that we haven’t discovered the bodily sources of mental disorders does not mean that we won’t succeed in the future. We have certainly made discoveries in this direction: Not only do we know now that it is impossible to be sad or mad without a brain, but we also know what specific brain part or substance is required. But even after all the advances in neurology, still no neurologic exam is indicated for the diagnoses of mental disorders, and for good reason. Because ultimately, what decides if someone has a mental disorder or not are arbitrary criteria. The fact that homosexuality is no longer a mental illness is only because of the fact that society has shifted its values towards the acceptance of diverse sexual orientations, were it not for that fact we would speak about the “homosexual brain” just as we know speak about “the depressed brain”. We could also speak about “the carpenter brain” or “the the writer’s brain”, and treat all of those conditions as illnesses.

In conclusion, I believe that contemporary psychopathology is a case of finding a hammer and suddenly realizing we are surrounded by nails. If something can be treated as an illness it will be treated as an illness, because that is l’esprit de l’époque. Classifying something as an illness, assigning it a part of the brain, and prescribing it a drug as treatment makes it real and important, so politicians, scientists, and the general public are aware of its existence and direct resources its way. This is why everyday we “discover” that there are more things linked to mental health: Poor housing, poor nourishment, the weather, sexual orientation, racial discrimination, political ideologies… and as there is no psychopathology there’s no limit to psychic pathologies. There’s a drug for everything or a therapy for everything. It’s no coincidence that we now have the most effective treatments in history and the highest rate of accessibility to mental health services ever, but the rates of mental disorders are soaring well. And despite all the advances in psychotherapy and psychopharmacology, no breakthroughs have been made in psychopathology.

I’m convinced that in the future people will look at our ideas on psychopathology as we now look at humorism.

Sources:

APA Definition of Psychopathology: https://dictionary.apa.org/psychopathology

*Psychotherapy just as effective as pharmacotherapy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244449/

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This suggests current analytic approaches in neuroscience may fall short of producing meaningful understanding of neural systems, regardless of the amount of data.

Uh.. The paper you linked is at least 50% of an academic shitpost or meme.

I'm not kidding. I've read it before.

It has legitimate arguments about neuroscience and the validity of their analysis tools, but those tools were not designed to analyze Von Neumann architectures and transistor based circuits.

I'm not a neuroscientist, but the principles of neuroscience are both not designed for the task these guys did (and they did it at least partially as a joke) and have proven results elsewhere. Further, we have better options for circuit analysis in silicon and don't have them in neurology, so the paper correctly points out that they're flawed, we just don't have better alternatives but are working on them.

We understand a great deal about many individual pathways in the brain, such as the optic pathways, and there are hundreds of different pathways we know a great about down to the neuronal level while being very far from being able to tell what any arbitrary neuron does.

This is because neurons are complex. It takes 1000 ML neurons to simulate a single biological neuron, but guess what, it's been done.

https://www.quantamagazine.org/how-computationally-complex-is-a-single-neuron-20210902/

When the guy tried to parachute off the Eiffel tower, he did so because he'd tested the idea with models first and had some direct evidence of the thing he was attempting to harness

He didn't test it enough. His friends literally begged him to try his apparatus with a dummy before he used it himself, but he was too proud and confident in his invention.

https://en.wikipedia.org/wiki/Franz_Reichelt#:~:text=Franz%20Karl%20Reichelt%20

From his arrival at the tower, however, Reichelt made it clear that he intended to jump himself. According to a later interview with one of the friends who accompanied him up the tower, this was a surprise to everybody, as Reichelt had concealed his intention until the last moment.[9] His friends tried to persuade him to use dummies in the experiment, assuring him that he would have other opportunities to make the jump himself. When this failed to make an impression on him, they pointed to the strength of the wind and said he should call off the test on safety grounds, or at least delay until the wind dropped. They were unable to shake his resolve;[7] seemingly undeterred by the failure of his previous tests, he told journalists from Le Petit Journal that he was totally convinced that his apparatus would work, and work well.

Trust me that I have the common sense not to do that. I meet the low bar of not being insane.

You all share the conviction that the human mind is arbitrarily tractable, controllable, malleable, that Selves can be engineered with no regard to their own will, and despite all evidence to the contrary.

There are many ways to control the human mind.

The only natural category these lot have is that they were completely wrong, and it's a bit rich to make that assertion about me when I'm discussing what I have clearly labeled as an extremely difficult engineering challenge. What else do you think that my belief that it would take us several decades to get there (in the absence of AI) means?

No, I think you're straightforwardly wrong about what is possible right now, and especially about what it shows. I don't think scientists can "emulate a rat brain", meaning create a digital simulacrum of a rat that allows them read/write access to the equivalent of a live rat brain. I certainly do not believe that scientists can emulate "1% of a human brain", under any reasonable interpretations of those words. My argument isn't that compute won't improve, it's that the mind is probably intractable, and that certainly no evidence of tractability is currently available. I have not looked into either the WBEP or EBRAINS, but I'm pretty confident they don't do anything approaching actual emulation of a human mind.

I never claimed that they have a virtual rat running around either. In this case, they managed to fully analyze the connectome of a rat, mapping all the neurons and their interconnections, but it takes much more than that to get an emulation running.

You need the actual weights of the neurons (in the ML sense), and for that you need optogenetics to study it, presumably in a live specimen, or you need to destructively scan the tissue with other techniques (if they were live when you started, they won't stay that way for long, hence why preserved tissue samples are used, including in the EU program. Besides, they only claim to have emulated 1% of the human brain, as a pilot program and technology incubator, your guess is as good as mine what running 1% of a brain does).

But looking back, I think it's pretty clear that this belief came from inference, not evidence, and from some pretty shaky inferences too. As you put it, "nothing in my knowledge of physics, chemistry, biology or engineering rules it out", and I wanted to believe it, and it fit neatly with other things I wanted to believe, so I discarded the contrary evidence and ran with it. That's what people do.

Do you think I peg my expected figure for how long it might take (counterfactual blah blah) because I am "discarding evidence"? No. It's because I have repeatedly acknowledged that it is an enormously difficult task.

Hell, if I was in charge of funding, I wouldn't put too much money into human brain emulation either, because AGI makes the wait-curves too steep. Anything we mere dumb humans do to painstakingly achieve that is likely going to be a waste of time and resources as opposed to a far more intelligent entity working on it, and we're building those even if they're decidedly inhuman.

Please, please, recognize the difference between "I know this is so" and "I don't know why this shouldn't be so". Both are useful; I argue that both are entirely necessary. But it pays to be clear about which one you're using in a given situation, and to not mix the two up.

Once again, if it's not contradicted by physics, then it's an engineering problem. We can emulate neurons, and to within the limits of measurement and innate noise, as the link to quanta shows.

It is a hard problem. It is still a problem that I expect will be solved eventually, and am reasonably confident I'll be alive to see it.