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Small-Scale Question Sunday for December 31, 2023

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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In the case of the common cold or the flu, prior infection to a previous strain isn't protective for the next one that does the rounds, which is why flu vaccines are refreshed annual (and designed pre-emptively, based on models of what the next strain might be).

If someone masked and avoided the flu, for say, 2 years, I strongly doubt they are at any additional risk if they stop masking or catch the next one despite masking.

I think I disagree with the statement that various types of flu/colds do not generate any immunity: they simply fail to generate sufficient immunity to avoid symptomatic infection, which is why the new strains are able to circulate in the fairst place.

Now you can reasonably disagree that this cross-reactivity actually matters in terms of disease length/prognosis if you're still not immune enough to avoid getting ill, and I'm not sure whether it has been tested empirically. But it makes intuitive sense at least, and the principle seems to be accepted e.g. in this 2009 paper looking at swine flu immunity in the general population https://www.pnas.org/doi/abs/10.1073/pnas.0911580106

Overall, seems like a hard thing to study. Would be interesting if someone did an East/West study on whether flu is actually worse in the East due to reduced exposure (noting that it might still be less prelevant on the net due to effective masking). I would fall back on the statement that either masks are effective and decrease your exposure to disease and therefore your immunity relative to the unmasked population, or ineffective and therefore pointless.