Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?
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Notes -
Inherently? Surely not. This is just a vague heuristic, and I'd be shocked if it was actually a universal rule. It just seems that there are some pathways to "make brain quiet down now" that don't do so perfectly gently, which a priori isn't too surprising. General anesthesia and alcohol are the two other examples that come readily to mind. So when I see a new drug that has that effect, and there's no safe explanation (like for melatonin) apparent, I wonder if it's doing so unsafely.
I don't worry too much though. I've had general anesthesia once, and I wouldn't hesitate to take Benadryl after an allergic reaction, because I doubt the costs outweigh the benefits, and I had a glass of wine with dinner tonight, because YOLO.
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