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Notes -
The idea of the show was "Sherlock Holmes as a doctor". So instead of Holmes and Watson you have House and Wilson solving medical mysteries. By the time it aired Wilson ended up as his old friend and House mostly works with his team of younger doctors.
House's personality is pretty close to what we got in shows like BBC's Sherlock. It's probably true to the Holmes novels, but I haven't read them.
It's true to a version of Holmes character, but House is much more of an asshole about things. Holmes is very smart, at the start not very sympathetic to human failings, and quite prepared to break the law in some instances (that's where House's burgling and breaking into patient's houses comes from). Most of it came from the first novel, "A Study in Scarlet", and the character was softened a little as Conan Doyle developed them:
But he is also able to be polite and even sympathetic to clients, and is mostly brusque to the rich and important who think they can just order him around. He doesn't have a chip on his shoulder about the world. BBC Sherlock upped the arrogance (for the younger version of Holmes which he was) and made him a bit more of an asshole than the Conan Doyle version, and House was just out-and-out arrogant and unpleasant, even with the excuse of the constant pain he was in.
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