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Wellness Wednesday for May 24, 2023

The Wednesday Wellness threads are meant to encourage users to ask for and provide advice and motivation to improve their lives. It isn't intended as a 'containment thread' and any content which could go here could instead be posted in its own thread. You could post:

  • Requests for advice and / or encouragement. On basically any topic and for any scale of problem.

  • Updates to let us know how you are doing. This provides valuable feedback on past advice / encouragement and will hopefully make people feel a little more motivated to follow through. If you want to be reminded to post your update, see the post titled 'update reminders', below.

  • Advice. This can be in response to a request for advice or just something that you think could be generally useful for many people here.

  • Encouragement. Probably best directed at specific users, but if you feel like just encouraging people in general I don't think anyone is going to object. I don't think I really need to say this, but just to be clear; encouragement should have a generally positive tone and not shame people (if people feel that shame might be an effective tool for motivating people, please discuss this so we can form a group consensus on how to use it rather than just trying it).

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A few months ago I overworked my shoulder, and my PT said I should take some indomethacin. I took some, and woke up because I was wheezing and barely breathing. Okay, maybe that was a bad idea. I also kept having a weird dry cough after doing the warm-up stretches, but the lungs are kinda my weak point, so I didn't worry too much.

A month ago I went to see an ENT doc about my nose. He took a look at it, found some polyps and sent me to an allergologist. The allergologist asked some weird questions that I thought had nothing to do with my nose, mentioned something called biologics, took some tests and sent me to the lab to do some blood tests. I kinda put it on the back burner.

This weekend I had a headache, my wife suggested I take ibuprofen, so I did. Guess what? Wheezing and barely breathing again. After taking some glucocorticoids I had left I went online to find out what that kind of reaction to NSAID means, and everything fell into place.

Those weird questions that I thought had nothing to do with my nose? She was pattern-matching my symptoms to AERD. AERD is a possibly autoimmune disease that is identified by the Samter's triad: asthma, nasal polyps and NSAID intolerance and usually manifests in mid-30's:

  • mid-30's? check

  • no issues with any of these symptoms before? check

  • NSAID intolerance? check

  • polyps? check

  • asthma? remember that weird dry cough I had after doing the stretches? I actually had it after doing the running before the stretches

So now I'm waiting for my blood tests to come back and will be going to the doc to confirm the diagnosis. I hate to be one of these people who self-diagnose themselves after going on the internet, but it really looks like AERD.

The good news: my symptoms are rather mild, as long as I avoid any NSAID medications.

The bad news: AERD can be treated, not cured. If (when) the symptoms get worse, I'll need to stay on glucocorticoids and probably start aspirin desensitization. If they get really bad, I'll need to start taking the aforementioned "biologics" - monoclonal antibodies that are much more effective and expensive immunosuppressants than glucocorticoids. But let's hope it won't get to that, and maybe our new AGI overlords will come up with a cure in the meanwhile.

Any idea what causes this? Just another big question mark in the autoimmune basket?

As far as I have learned, yes.