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You've glossed over the question of "how do we define 'humans'" - even repeating "human's have two legs" after my questions about bipedalism. "Humans have two legs" sounds right from my point of view, just like "neohumans have infrared vision" would from theirs, but an Ardipithecus ancestor might think I was just an unnatural change, hopelessly bad at palm walking on my dwindling forelegs. From my ancestors' point of view, am I a natural human, or a deviation from Australopithecus? This question is isomorphic to "will any transhuman descendants of mine be natural transhumans, or deviant humans", save for special pleading.
If we're going to focus on the ground level, look at what we literally find in the ground. Fossils, of a connected web of species, none of which exist except as a series of changes to their ancestors. "Don't make biological improvements" is positively false, and normatively it isn't a "Law" that would preserve some definition of human, it is a rule under which humans would never have existed. Setting aside God(s) doesn't make this idea of Natural Law more defensible, because even just setting aside Young-Earth Creationism begins to make it incoherent. "What is natural for humans" is a dissolved question once you realize that the implicit presupposition of a well-defined "humans" category in space-time is a false premise. Anthropocentrism might have been a reasonable null hypothesis, before we knew any better, but at this point "why are nearly-human creatures so unnatural" makes about as much sense as "why are the stars so tiny". The stars aren't tiny, but realizing that for all but one of them requires perceiving things so far away in space that it requires careful thought for us to realize the exception is just another star rather than a special singleton category of "sun". Non-homo-sapiens hominids aren't unnatural, but realizing that for all but one of them requires perceiving things so far away in time that it requires more careful thought for us to realize the exception is a single link in a chain rather than a special singleton category of "human".
Even "how do we define 'healthy'" isn't a trivial question either.
Do we? Not a rhetorical question - has the Hygiene Hypothesis been definitively refuted? Last I heard, there was evidence that "never get an infectious illness", even aside from increasing the dangers of any later infection, might also increase the risk of asthma and other autoimmune disorders.
And that's just counting the microorganisms which generally cause illness - breeding completely "germ-free organisms", with no microbiome at all, is even more fraught. For some for the very same microorganisms which cause illnesses in rare excess, the absence of those microorganisms seems to cause autoimmune inflammatory disorders if they're removed. Animals have evolved with asymptomatic infections of dangerous bacteria for so long that we don't actually have the capability of remaining healthy while uninfected! Are pathobionts' presence mandated by Natural Law? Is the answer immutable, or contingent on whether we can discover a safer artificial substitute to expose our immune systems to, like we did with polio?
I strongly agree, and since human hearts have a distressing tendency to stop pumping before the rest of the human is ready, I hope neohuman hearts are more capable. By your definition, that would make them more "natural" than us, right? Similarly, it also doesn't seem that an eye whose sensitivity stops at 750nm is just as good as one that can see to 800nm or 850nm. We might thus conclude "neohuman eyes and hearts are more natural than human ones", or at our most justifiably parochial we might say "neohuman eyes are natural to neohumans, human eyes are natural to humans", but for us to say "neohuman eyes are unnatural" would make about as much sense as a non-primate mammal saying "primate eyes are unnatural" (does anyone really need a third visual opsin?) and less sense than a typical bird or fish saying so (wouldn't you agree that losing two independent dimensions of color vision wasn't just as good as keeping them, even if we eventually reevolved one dimension back?).
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