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To What Extent are Humans Optimized?

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minimizing how many instructions you need to add to the genome in order to make something happen

This is the mechanism for why the body isn't fully optimized: it has to be backwards compatible and build iteratively off of previous DNA. That tech debt is exactly what an artificial engineered brain/body could re-design.

That makes sense, direct editing is going to cause a lot of indirect problems. Similar to immune system or dietary supplements.