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To What Extent are Humans Optimized?

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If the question is "how good are human brains compared to alternatives" ... given we know basically nothing about how either of these actually work, in the sense of 'creating large-scale knowledge or behavior', there's not really anything we can say?

"Substrate"-wise, presumably if neurons are "doing something" superconducting wires, or just silicon, could "do" that much faster, action potentials are quite a few orders of magnitude away from optimal for transmitting a few bits, either in energy or time. But I'm not sure how that relates to the overall question.

There is a lesswrong post with ~200 upvotes that goes into detail on this. Unfortunately, it's, as far as I can tell, mostly bullshit, and is mostly applying mathematical ideas outside contexts they make sense / (unintentional) Eulering. https://www.lesswrong.com/posts/xwBuoE9p8GE7RAuhd/brain-efficiency-much-more-than-you-wanted-to-know

Appreciate the lesswrong link. I'm interested in conjecture and wild predictions and I don't particularly care about accuracy so its exactly what I'm looking for.