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Genuinely great post, man, thanks for writing it.
OP doesn't even need to wait, I got semaglutide from this chinese source for roughly 7USD per 2mg, and it's worked wonders for the past 2 months.
I'd love to know more. How do you handle reconstituting and injecting it? What's your weight loss been like? Any other effects?
I assume that the website you're getting it from is a compounding pharmacy.
I'm not huge but I could stand to lose 10kg or so, and if I can take a weekly shot to make it happen, I would definitely consider it. Only the price has kept me from trying it so far.
Oh it's nothing so official. I don't have a prescription for semaglutide, so I've had to find sources that don't ask for it, the chinese website I linked is one such source. If you press "contact" on that website and send a message to the guy, he'll send you a whatsapp phone number, though which you chat with him about what you want, I bought 10 vials of 2mg semaglutide. Payment is through a payment processor like moneygram or wise, but in the end these are just middlemen which also accept credit cards (though there are some annoying verifications you have to go through, I had to send a picture of my drivers license).
I took a picture of what actually arrived, inside sealed packaging depicting some sort of chinese female-targeted face mask (so it better evades customs), you can see in the background the other 9 flasks.
To reconstitute it, you need to buy bacteriostatic water (I bought it from here, no need for prescription or anything). You need 2 different syringe types, the first one I use is a 1ml syringe to draw up water from the bac-water bottle and reconstitute the solution, and a second 0.3ml insulin syringe I use to actually inject. Most of the complexity of doing this water manipulation is being aware that drawing up water creates a vacuum in the bottle, so when you draw up 0.25ml in your insulin syringe, you first need to inject 0.25ml of air inside the bottle to maintain the same end-pressure. You need to also buy alcohol prep pads to clean every surface that the needle will touch (the top of all bottles, and the skin) about a minute before the needle goes in.
Semaglutide is a lot more stable than other peptides at room temperature, in lyophilized form at room temperature there was basically no degradation after a month, which means that you can keep it for a while in that form without risk. Reconstituted it's also stable at room temp for a few weeks.
Now onto the effects and protocol:
First, the main effects: this stuff has a massive, just massive dose-dependent effect on appetite. In my default state, I need to eat around 3500 calories (at my current 230lbs, around 27% body fat level) not to feel hungry going to bed. Semaglutide at the 1mg/week level made that drop to needing 2200 calories to feel completely satiated at the end of the day. It both seems to cause food to stay in my stomach longer, and cause hormone signalling to make my brain not crave food. I've lost 2 to 3 lbs per week over the past month following my current 2000cal/day diet. I did not notice any other effects apart from appetite suppression and very, very slight and infrequent nausea. I'd suggest to have a formal diet plan if you want to lose weight, and semaglutide will make it effortless for you to stick with it.
I started not with the injectable version, but with the oral version of semaglutide called Rybelsus (which I got without prescription from indiamart). The oral version has much lower bioavailability, so you need to take it everyday in the morning on an empty stomach with max 100ml of water and wait at least 30min before eating anything else, otherwise the absorption is shit. The recommendation is to start with the 3mg/day version for a month, then upgrade to 7mg/day for a month, then again to 14mg/day, at which point you can switch to an equivalent injectable dose of 0.5mg/week (this shows just how badly semaglutide is absorbed in the gut). The important thing to know is that semaglutide has a half-life of a whole week, so the equilibrium point of a 1mg/week dose is really 2mg flowing in your blood, which you get to after about a month at the same dose.
I didn't follow the recommended dosing, I did 10 days at 3mg oral, then 10 days at 7mg oral, then 2 weeks at 0.5ml/week injectable, then 2 more weeks at 1.0ml/week injectable. The whole point of going up slowly is to prevent gastrointestinal side-effects, which are by far the most reported side-effects in trials. I didn't get much stomach disruption, but I did notice that I got it more with the injectable than the oral, so I think it's the sudden spikes of semaglutide that are to blame, this made me switch to a 3x/week injection with smaller amounts, and it seems to have solved it. Insulin needle injections are nothing like the intramuscular vaccines or anything, the needle is absolutely tiny and doesn't hurt at all, like, me pinching my leg fat to create a suitable injection site hurts more than the needle going in.
images:
https://ibb.co/8drpxw4
https://ibb.co/RzD6hLG
https://ibb.co/2nf6txP
https://ibb.co/J3mnkVW
https://ibb.co/FnTsLhz
Thanks, that's super helpful.
I imagine I will stick to the oral version if I do take the plunge. Taking a pill is easier than explaining to my girlfriend why I'm shooting up once a week. Looks like the price from Indiamart is about half what I would pay from a UK supplier.
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