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There must be some pleiotropy, because most species sit in local optima for most of the time.
You know, there isn't that a 4-million dataset is open for everyone for study. For privacy reasons, large GWAS studies are only combing linear correlations together. We know incest is bad yet those GWAS studies fail to show it. This is very crude model and you shouldn't take it too seriously.
examples
Pursuing search for eternal life instead of reproducing oneself.
Low SMV (for men), ceteris paribus.
Being a cuck.
Writing long, elaborate, texts into defence for being a cuck.
In a broad sense 'antagonistic pleiotropy' is everywhere, stuff like having a human-sized brain means you are intelligent but consume more energy, better wound healing -> cells that replicate more -> cancer, etc.
That's different from antagonistic pleiotropy among existing, common genetic variants in the current human population, which (according to steve, by my memory) is uncommon.
Among animals in general, this meta-analysis found that inbreeding is very common and often not avoided at all.
I don't think Hsu is that concerned antagonistic pleiotropy. I think he'd prefer increasing IQ via PGS even if it's say decreased athleticism and many other traits.
Isn't it that to getect genetic effect, we need sample size of N, but to detect pleiotropy, we need N^2?
I don't understand your point here, avoiding it has costs also. Doesn't mean it's bad for individual.
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