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bolido_sentimental  1yr ago (text post)   4133 thread views

Small-Scale Question Sunday for December 25, 2022

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tl;dr I’m not worried

The simple reason vaccination correlates with mortality is that vaccination correlates with age. (Insert caveats about youth vaccination tradeoffs here.) Last I heard vaccination was still protective against hospitalization and mortality from C19, which seems the most relevant metric here, tho I’m happy to update if you have new data.

Vaccine protection has been fading since V1, but my priors are that immune evasion is more important than diminishing immune response. But… mRNA vaccines are brand spanking new, so we don’t know fully understand their limitations and possibilities fully. If mRNA approaches linger and cause a different type of immune response than traditional vaccines then maybe we can’t use them for longer term protection. Or, maybe we can use this vector to inhibit certain types of autoimmunity; a cure for rheumatoid arthritis or multiple sclerosis would be tremendous. It’s still very early days so I take quite seriously the possibility that mRNA vaccines have serious problems, but the stuff I’ve seen to date, including the links above, have yet to convince me of this thesis.

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