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Small-Scale Question Sunday for February 23, 2025

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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other vaccines have mostly been around long enough to feel good about this

This suffers from precisely the same issue as talking about e.g. refrigerants. There have been those that stood the test of time - that you can no longer purchase.

Or to put it another way: let's talk excipients.

their isn't a good explanation for how that would biologically happen however.

"drop dead in 20 years" is a blatent example to illustrate the point.

I am far more concerned in practice about things like, oh...

"This causes you to express a particular IgG antibody. Oops, said antibody breaks oocytogenesis. Oops, now any of your subsequent female children have nonviable oocytes". As this is something that:

a) has massive longterm effects (infertility of female offspring).
b) is essentially completely invisible for ~15 years or so.
c) is nontrivial to figure out even down the line.