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People aren't bothered as much by infectious diseases as in the past so the selection for disease resistance is probably lessened, and we can expect immune systems to weaken or become dysfunctional due to random drift. We have basically removed all selection pressures other than fecundity for modern-day humans, so everything that evolution used to optimize for besides fecundity will be expected to decline.

Weakening selection for a trait isn't same as selection for lower values of a trait (as with "too stupid to use contraception => more children"). I think SMV is still selected and I think immune system somehow influences SMV.