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naraburns  nihil supernum  2yr ago (text post)   3079 thread views

Friday Fun Thread for November 4, 2022

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Yeah, a lot of organic material depends on how its twisted up (conformation), and the shape is governed by a bit from over here being attracted to a bit from over there due to ionic charge, hydrogen bonding, etc.--things that are not standard atom-atom covalent bonds. Those secondary types of linkage either form more easily or get disrupted more easily depending on pH, temperature, and solvent type. Something is "denatured" when its useful twisty conformation is untwisted, which makes it not useful. Depending on the organic material you're talking about, sometimes restoring it to a friendly environment will cause it to re-twist back into its useful conformation, but other times the sticky pieces just glom onto matching sticky bits elsewhere and you just get a mess. (A lot of cooking is based on this process; intentionally denaturing some components of ingredients using acid/heat/water, and then cooling the result into a different state.)

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