I currently hold a similar position wrt. efficacy vs. active harm. The claims of drugs being actively harmful to the population seem like they mostly come from Gøtzsche's work. I do not know whether or by how much he may have exaggerated these claims. In the meantime, here's all the references on harm I could find from this post:
On BIA 10-2474:
Butler, D., & Callaway, E. (2016, January 21). Scientists in the dark after French clinical trial proves fatal. Nature, 529(7586), 263–264. https://doi.org/10.1038/nature.2016.19189
On fialuridine:
Honkoop, P. Scholte, H. R., de Man, R. A., & Schalm, S. W. (1997). Mitochondrial injury: Lessons from the fialuridine trial. Drug Safety, 17(1), 1–7. https://doi.org/10.2165/00002018-199717010-00001
Wadman, M. (2006, March 23). London's disastrous drug trial has serious side effects for research. Nature, 440(7083), 388–389. https://doi.org/10.1038/440388a
The bulk of Peter C. Gøtzsche's claims (which probably contain several more references):
Gøtzsche, P. C. (2013). Deadly medicines and organized crime: How big pharma has corrupted healthcare. CRC Press. https://doi.org/10.1201/9780429084034
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Notes -
I currently hold a similar position wrt. efficacy vs. active harm. The claims of drugs being actively harmful to the population seem like they mostly come from Gøtzsche's work. I do not know whether or by how much he may have exaggerated these claims. In the meantime, here's all the references on harm I could find from this post:
On BIA 10-2474:
Butler, D., & Callaway, E. (2016, January 21). Scientists in the dark after French clinical trial proves fatal. Nature, 529(7586), 263–264. https://doi.org/10.1038/nature.2016.19189
On fialuridine:
Honkoop, P. Scholte, H. R., de Man, R. A., & Schalm, S. W. (1997). Mitochondrial injury: Lessons from the fialuridine trial. Drug Safety, 17(1), 1–7. https://doi.org/10.2165/00002018-199717010-00001
On TGN1412:
Attarwala, H. (2010). TGN1412: From discovery to disaster. Journal of Young Pharmacists, 2(3), 332–336. https://doi.org/10.4103/0975-1483.66810
Wadman, M. (2006, March 23). London's disastrous drug trial has serious side effects for research. Nature, 440(7083), 388–389. https://doi.org/10.1038/440388a
The bulk of Peter C. Gøtzsche's claims (which probably contain several more references):
Gøtzsche, P. C. (2013). Deadly medicines and organized crime: How big pharma has corrupted healthcare. CRC Press. https://doi.org/10.1201/9780429084034
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