Man, this would be really bad if there was any evidence at all whatsoever other than one paper about statistics that makes no specific testable claims, and also didn't require the reader to ignore 200 years of history.
There are arguments to be made re. drug getting soft-pedaled in trials vis. effectiveness; believing they are soft-pedaled re. harm requires a level of alternate reality living that is frankly impressive.
I currently hold a similar position wrt. efficacy vs. active harm. The claims of drugs being actively harmful to the population seem like they mostly come from Gøtzsche's work. I do not know whether or by how much he may have exaggerated these claims. In the meantime, here's all the references on harm I could find from this post:
On BIA 10-2474:
Butler, D., & Callaway, E. (2016, January 21). Scientists in the dark after French clinical trial proves fatal. Nature, 529(7586), 263–264. https://doi.org/10.1038/nature.2016.19189
On fialuridine:
Honkoop, P. Scholte, H. R., de Man, R. A., & Schalm, S. W. (1997). Mitochondrial injury: Lessons from the fialuridine trial. Drug Safety, 17(1), 1–7. https://doi.org/10.2165/00002018-199717010-00001
Wadman, M. (2006, March 23). London's disastrous drug trial has serious side effects for research. Nature, 440(7083), 388–389. https://doi.org/10.1038/440388a
The bulk of Peter C. Gøtzsche's claims (which probably contain several more references):
Gøtzsche, P. C. (2013). Deadly medicines and organized crime: How big pharma has corrupted healthcare. CRC Press. https://doi.org/10.1201/9780429084034
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Notes -
Man, this would be really bad if there was any evidence at all whatsoever other than one paper about statistics that makes no specific testable claims, and also didn't require the reader to ignore 200 years of history.
There are arguments to be made re. drug getting soft-pedaled in trials vis. effectiveness; believing they are soft-pedaled re. harm requires a level of alternate reality living that is frankly impressive.
I currently hold a similar position wrt. efficacy vs. active harm. The claims of drugs being actively harmful to the population seem like they mostly come from Gøtzsche's work. I do not know whether or by how much he may have exaggerated these claims. In the meantime, here's all the references on harm I could find from this post:
On BIA 10-2474:
Butler, D., & Callaway, E. (2016, January 21). Scientists in the dark after French clinical trial proves fatal. Nature, 529(7586), 263–264. https://doi.org/10.1038/nature.2016.19189
On fialuridine:
Honkoop, P. Scholte, H. R., de Man, R. A., & Schalm, S. W. (1997). Mitochondrial injury: Lessons from the fialuridine trial. Drug Safety, 17(1), 1–7. https://doi.org/10.2165/00002018-199717010-00001
On TGN1412:
Attarwala, H. (2010). TGN1412: From discovery to disaster. Journal of Young Pharmacists, 2(3), 332–336. https://doi.org/10.4103/0975-1483.66810
Wadman, M. (2006, March 23). London's disastrous drug trial has serious side effects for research. Nature, 440(7083), 388–389. https://doi.org/10.1038/440388a
The bulk of Peter C. Gøtzsche's claims (which probably contain several more references):
Gøtzsche, P. C. (2013). Deadly medicines and organized crime: How big pharma has corrupted healthcare. CRC Press. https://doi.org/10.1201/9780429084034
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