site banner
PaperclipPerfector  3d ago (text post)   1431 thread views

Small-Scale Question Sunday for December 1, 2024

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

1
Top Bottom Old Controversial Comments
Jump in the discussion.

No email address required.

If we know how to make a vaccine for it, why was it not included in the annual flu vaccine this year? I was assuming the reason is that we don't know how to make a vaccine for a potential future H5N1 that can sustain human-to-human transmission because it doesn't exist and may be sufficiently different from the currently known strains that a different vaccine may be necessary (or, worse, that immune imprinting may mean a future vaccine against the pandemic strain wouldn't work as well).

Uhhhhhh I don't want to do a lit review so please forgive me if I get some of the details wrong but basically they try and predict well in advance which mutations are going to be prevalent the next year (like almost a year in advance) and make all the vaccines accordingly. The mutations are typically pretty well understood, that's what the H and Ns are about.

This is also why the flu vaccine doesn't always stop the flu, you can end up with one of the other variations, which annoys people to no end and makes them feel like it's pointless, it's not.

I believe the specific issue with H5N1 is that it stays trapped in the lower lungs which makes it even more dangerous (because you get more ARDS) but less contagious since you have less of the virus carried in cough and so on. The specific elements responsible for this are not necessarily in the same place in other animals, which can be why something is virulent in pigs or whatever but not humans.

My favorite example of this is the fact that allergic reactions for dogs are more diarrheal as opposed to throat closing, because that's where the histamine receptors are mostly located in dogs.

Uhhhhhh I don't want to do a lit review so please forgive me if I get some of the details wrong but basically they try and predict well in advance which mutations are going to be prevalent the next year (like almost a year in advance) and make all the vaccines accordingly.

So it's more that a year ago or whenever they were actually selecting the strains for this year, H5N1 wasn't looking as scary, but maybe it could be included in next years' (assuming we don't get a pandemic and manage to rush a separate vaccine before then)?

Yeah my understanding is that we are sitting on a stockpile of at least 5 mill doses, and our routine process could be reasonably effective at dealing with this without resorting to "novel" technologies, but it's very severe and potentially a fast moving problem.

What is this place?

This website is a place for people who want to move past shady thinking and test their ideas in a court of people who don't all share the same biases. Our goal is to optimize for light, not heat; this is a group effort, and all commentators are asked to do their part.

The weekly Culture War threads host the most controversial topics and are the most visible aspect of The Motte. However, many other topics are appropriate here. We encourage people to post anything related to science, politics, or philosophy; if in doubt, post!

Check out The Vault for an archive of old quality posts. You are encouraged to crosspost these elsewhere.


Why are you called The Motte?

A motte is a stone keep on a raised earthwork common in early medieval fortifications. More pertinently, it's an element in a rhetorical move called a "Motte-and-Bailey", originally identified by philosopher Nicholas Shackel. It describes the tendency in discourse for people to move from a controversial but high value claim to a defensible but less exciting one upon any resistance to the former. He likens this to the medieval fortification, where a desirable land (the bailey) is abandoned when in danger for the more easily defended motte. In Shackel's words, "The Motte represents the defensible but undesired propositions to which one retreats when hard pressed."

On The Motte, always attempt to remain inside your defensible territory, even if you are not being pressed.


New post guidelines

If you're posting something that isn't related to the culture war, we encourage you to post a thread for it. A submission statement is highly appreciated, but isn't necessary for text posts or links to largely-text posts such as blogs or news articles; if we're unsure of the value of your post, we might remove it until you add a submission statement. A submission statement is required for non-text sources (videos, podcasts, images).

Culture war posts go in the culture war thread; all links must either include a submission statement or significant commentary. Bare links without those will be removed.

If in doubt, please post it!


Rules


Recommended Posts And Communities

Recommended Realtime Chats