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Notes -
Hmm.. I actually went into depth on melatonin recently for a journal club presentation, and looked into the papers Scott cited. It seems quite robust to me, at least the core claims that 0.3 mg is the most effective dose, though I don't know how that stacks up with current higher dose but modified release tablets (those are popular in the NHS).
Basically there's a lot of evidence and belief it does nothing at all so that the dose doesn't matter. This is countered by people who believe it works great in at least certain settings (ex: "well for general outpatient management no, but for acute crisis in mental hospital/inpatient ward..."). Some people will also argue that you need spaced dosing for efficacy and that that is more important for dosing.
Fundamentally it is extremely hard to do insomnia research because getting the right population slice is challenging. Pursuant to that, it may also be culturally dependent and a million other annoying things.
Stick with what the research YOU find and YOUR attendings say (with the later being important to wellness lol).
If you look at say Trazodone we have a lot of papers and guidelines in the U.S. saying it doesn't do shit.....but then some newer papers saying it's doing some weird stuff and thats the cause of the subjective improvement in symptoms. It is a mess and you'll see a variety of strong and seemingly evidence based opinions.
Saw your PM will reply when I get a chance, I think that needs more attention.
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