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PaperclipPerfector  25d ago (text post)   2848 thread views

Small-Scale Question Sunday for October 27, 2024

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

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3000 milligrams of acetaminophen in one dose is dangerous to your liver. That’s one third higher than the recommended maximum dose for a entire day. 4000 would be double the maximum allowed daily dose. Especially if you regularly drink any alcohol at all. Can you ask your doctor to put some lidocaine on your face before he starts? Or use an injected numbing agent?

[3000mg is] one third higher than the recommended maximum dose for a entire day. 4000 would be double the maximum allowed daily dose

The source I linked in the toplevel says that 3000mg would be the “Safest maximum daily dose for most adults” and that 4000 is the maximum allowable 24h dose. Where are you getting your numbers from?

I do not take pain relievers for any other purpose; I had to buy a bottle of acetaminophen specifically for this use.

Especially if you regularly drink any alcohol at all.

I have 2 drinks per week for good health superstition, but will obviously refrain for the week surrounding that dose.

Can you ask your doctor to put some lidocaine on your face before he starts?

At the technician's recommendation, I already did try lidocaine, but I'm not sure how much it helped, so I'm going to be using a higher dose next time. (This clinic doesn't seem to include it with service, in any case.)

A few years ago 4000 was the maximum daily dose but the FDA has recently revised the recommendation down to 2000 mg because of evidence that acetaminophen is more hepatotoxic that previously realized. And to reduce the risks of accidental overdose from multiple medications, and because of the synergistic damaging effects with alcohol.

I've got to ask again where you are getting those numbers from.

I googled fda.gov acetaminophen safety and the first result, explicitly labeled “current as of” February of this year, has the same number as the Harvard article I cited in the toplevel comment:

The current maximum recommended adult dose of acetaminophen is 4,000 milligrams per day

https://www.fda.gov/consumers/consumer-updates/dont-overuse-acetaminophen

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